I guess my question would be different POI at what range? Perfectly regulated barrels would still have different POI outside of the yardage it's regulated to (typically 40yds, I believe). Meaning if you shot both at 20 or both at 60 they'd shoot different POI. That's natural for them to shoot different horizontal planes on a SxS and different vertical planes on an O/U. Where you'd run into trouble is either of those vice versa.
My SxS shoots true vertically which is great but given what I want that gun to do requires holdover to compensate for the regulation. The tight barrel is sighted in for 40yds and that requires that I hold about five inches or so left with my open barrel at 10-20yds which is the range that I want that open barrel to shoot. What I'm getting at is that, just like all turkey guns, you're asking the shotgun to do something that it wasn't exactly designed to do, whether that be shoot like a rifle or whether that be have two barrels that shoot true to a single POA but at two different, desired yardages.
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