Lots of folks have mentioned permethrin already, but highly recommend using gaiters in addition if you're in a tick-heavy area. They don't have to be heavy-duty ones... anything that forces them to walk over the permethrin-treated clothing instead of sneaking between your boots/pant legs straight to your skin.
The knee-high Gore-tex gaiters are super unnecessary and will make you sweat, but there are some lightweight mid-calf stretch nylon options that are perfect for this. I really like the First Lite Traverse, they are super lightweight/breathable and won't make you hot, but still good enough to keep the ticks out (get the large size, they run small). Probably some other brands out there that make similar.