Lead 6s will hammer turkeys to 40 yds, and it is easy to find a load that will exceed 100/10 @ 40. I would not hunt any shell that won't do 100/10 @ 40. That said, it is possible to get 5s to exceed 100/10 @ 40 but it may take some experimentation (which may be difficult this year). For me, that combo in my 1187 (12 ga/26") was Winch 3-2-5s at 113/10 and Winch 3-1.75-5s at 105/10 with an SSX .643 tube.