Depending on the time of year , but if you are looking to hit the mountains , I would spend a few days moving thru the Shenandoah Valley heading down from Winchester to Roanoke or so. Appalachian Mtns. to the west and Blue Ridge to the east with tons of of side trips. Skyline Drive , Blue Ridge Parkway lots of different caverns and rivers. May also want to consider Smith Mtn. Lake 30 min east of Roanoke . 20,000 acre lake with beautiful scenery , clean water and great striper fishing. Good luck in your travels...